Association of household food- and drink-sharing practices with human herpesvirus 8 seroconversion in a cohort of Zambian children

Date
2017-10-17
Authors
Crabtree, Kay L.
Wood, Charles
Wojcicki, Janet M.
Minhas, Veenu
Kankasa, Chipepo
Mitchell, Charles
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press for the Infectious Diseases Society of America
Abstract
Background: Human herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodeficiency virus type 1 (HIV-1) infection and risk for Kaposi sarcoma, but behaviors associated with HHV-8 transmission are not well described. Methods: We enrolled and followed a prospective cohort of 270 children and their household members to investigate risk factors for HHV-8 transmission in Lusaka, Zambia. Results: We report an incidence of 30.07 seroconversions per 100 child-years. Independent risk factors for HHV-8 incident infection included having a child who shared utensils with a primary caregiver (hazards ratio [HR], 2.33; 95% confidence interval [CI], 1.49-7.14), having an increasing number of HHV-8-infected household members (HR, 1.27; 95% CI, 1.09-2.79), and having >/=5 siblings/children in the household (HR, 2.24; 95% CI, 1.03-4.88). Playing with >5 children a day was protective against infection (HR, 0.54; 95% CI, .33-0.89), as was increasing child age (HR, 0.96; 95% CI, .93-.99). Conclusions: This is the first study to find a temporal association between limited child feeding behaviors and risk for HHV-8 infection. Child food- and drink-sharing behaviors should be included in efforts to minimize HHV-8 transmission, and households with a large number of siblings should receive additional counseling as childhood infections occur in the home context.
Description
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version, Crabtree KL, Wojcicki JM, Minhas V, Kankasa C, Mitchell C, Wood C. Association of Household Food- and Drink-Sharing Practices With Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children. J Infect Dis. 2017 Oct 17;216(7):842-849. doi: 10.1093/infdis/jix399, is available online at https://academic.oup.com/jid/article/216/7/842/4082466.
Keywords
Kaposi’s sarcoma, Human herpesvirus 8, Mastication, Africa, Sub-Saharan, Zambia, Herpesviridae Infections, Food microbiology
Citation
Crabtree KL, Wojcicki JM, Minhas V, Kankasa C, Mitchell C, Wood C. Association of Household Food- and Drink-Sharing Practices With Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children. J Infect Dis. 2017 Oct 17;216(7):842-849. doi: 10.1093/infdis/jix399.