Rapid appraisal project: Marik protocol for sepsis management

Do patients diagnosed with severe sepsis who are treated with hydrocortisone, thiamine, and vitamin C have a better prognosis than those treated with the current standard practice? Through extensive searching of the Cochrane Collection, PubMed, and the Bryan College of Health Sciences Library, this medication regimen effectiveness was analyzed. To research this regimen, three primary research articles were chosen. Because this topic is new, available research was limited. Criteria for the primary article included the full medication regimen, a critical care setting, and the diagnosis and prognosis of sepsis. Additionally, one systematic review was chosen that analyzed the effectiveness of hydrocortisone in the treatment of sepsis. To supplement the article and review, a registered nurse was interviewed. With over 30 years of experience in the intensive cardiac unit at an urban hospital, she detailed her experiences with sepsis and shared that this protocol has been in discussion at intensive care conventions. Through the research, we found that this protocol decreased mortality by 32%, decreased the need for dialysis by 17%, and decreased vasopressor use by an average of 35 hours. Ultimately, this medication regimen shows great potential but will need to be studied further before it becomes standard practice.
Sepsis, Marik Protocol, Vitamin C, Hydrocortisone, Thiamine
Aguilar, B., Holm, A., Klein, E. & Robinson, B. (2018). Rapid appraisal project: Marik protocol for sepsis management. Poster presented at Provost Colloquium, Evidence-Based Practice Presentations, Bryan College of Health Sciences, Lincoln, NE.