Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: The role of early childhood feeding practices

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dc.contributor.authorCrabtree, Kay L.
dc.contributor.authorWojcicki, Janet M.
dc.contributor.authorMinhas, Veenu
dc.contributor.authorSmith, David R.
dc.contributor.authorKankasa, Chipepo
dc.contributor.authorMitchell, Charles D.
dc.contributor.authorWood, Charles
dc.date.accessioned2019-02-24T20:22:28Z
dc.date.available2019-02-24T20:22:28Z
dc.date.issued2014-02
dc.descriptionThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Cancer Epidemiology, Biomarkers & Prevention following peer review. The definitive publisher-authenticated version, Crabtree KL, Wojcicki JM, Minhas V, Smith DR, Kankasa C, Mitchell CD, Wood C. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):300-8. doi: 10.1158/1055-9965, is available online at http://cebp.aacrjournals.org/content/23/2/300.long.en_US
dc.description.abstractBACKGROUND: Human herpesvirus-8 (HHV-8) infection in early childhood is common throughout sub-Saharan Africa with prevalence increasing throughout childhood. Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high concentrations in saliva. METHODS: To understand the horizontal transmission of HHV-8 within households to children, we enrolled for cross-sectional analysis, 251 households including 254 children, age two and under, in Lusaka, Zambia. For all children, plasma was screened for HHV-8 and HIV type I (HIV-1) and health and behavioral questionnaires were completed. Multilevel logistic regression analysis was conducted to assess independent factors for HHV-8 infection in children. RESULTS: Risk factors for HHV-8 infection included increasing number of HHV-8-positive household members [OR = 2.5; 95% confidence interval (CI), 1.9-3.3; P < 0.01] and having a primary caregiver who tested the temperature of food with their tongue before feeding the child (OR = 2.4; 95% CI, 1.93-3.30; P =0.01). Breastfeeding was protective against infection with HHV-8 for children (OR= 0.3; 95% CI, 0.16-0.72; P < 0.01). CONCLUSIONS: These results indicate that exposure to HHV-8 in the household increases risk for early childhood infection, with specific feeding behaviors likely playing a role in transmission. IMPACT: Interventions to protect children from infection should emphasize the possibility of infection through sharing of foods.en_US
dc.identifier.citationCrabtree KL, Wojcicki JM, Minhas V, Smith DR, Kankasa C, Mitchell CD, Wood C. Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: the role of early childhood feeding practices. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):300-8. doi: 10.1158/1055-9965.EPI-13-0730.en_US
dc.identifier.urihttp://cebp.aacrjournals.org/content/23/2/300.long#
dc.identifier.urihttp://hdl.handle.net/20.500.11987/349
dc.language.isoen_USen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.subjectHuman herpesvirus 8en_US
dc.subjectKaposi’s sarcomaen_US
dc.subjectHerpesviridae Infectionsen_US
dc.subjectFeeding behavioren_US
dc.subjectAfrica, Sub-Saharanen_US
dc.subjectZambiaen_US
dc.titleRisk factors for early childhood infection of human herpesvirus-8 in Zambian children: The role of early childhood feeding practicesen_US
dc.typeArticleen_US

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Crabtree, Kay L., PhD, RN
Crabtree, Kay L., PhD, RN