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Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: The role of early childhood feeding practices

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dc.contributor.author Crabtree, Kay L.
dc.contributor.author Wojcicki, Janet M.
dc.contributor.author Minhas, Veenu
dc.contributor.author Smith, David R.
dc.contributor.author Kankasa, Chipepo
dc.contributor.author Mitchell, Charles D.
dc.contributor.author Wood, Charles
dc.date.accessioned 2019-02-24T20:22:28Z
dc.date.available 2019-02-24T20:22:28Z
dc.date.issued 2014-02
dc.identifier.citation Crabtree KL, Wojcicki JM, Minhas V, Smith DR, Kankasa C, Mitchell CD, Wood C. Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: the role of early childhood feeding practices. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):300-8. doi: 10.1158/1055-9965.EPI-13-0730. en_US
dc.identifier.uri http://cebp.aacrjournals.org/content/23/2/300.long#
dc.identifier.uri http://hdl.handle.net/20.500.11987/349
dc.description This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Cancer Epidemiology, Biomarkers & Prevention following peer review. The definitive publisher-authenticated version, Crabtree KL, Wojcicki JM, Minhas V, Smith DR, Kankasa C, Mitchell CD, Wood C. Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):300-8. doi: 10.1158/1055-9965, is available online at http://cebp.aacrjournals.org/content/23/2/300.long. en_US
dc.description.abstract BACKGROUND: Human herpesvirus-8 (HHV-8) infection in early childhood is common throughout sub-Saharan Africa with prevalence increasing throughout childhood. Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high concentrations in saliva. METHODS: To understand the horizontal transmission of HHV-8 within households to children, we enrolled for cross-sectional analysis, 251 households including 254 children, age two and under, in Lusaka, Zambia. For all children, plasma was screened for HHV-8 and HIV type I (HIV-1) and health and behavioral questionnaires were completed. Multilevel logistic regression analysis was conducted to assess independent factors for HHV-8 infection in children. RESULTS: Risk factors for HHV-8 infection included increasing number of HHV-8-positive household members [OR = 2.5; 95% confidence interval (CI), 1.9-3.3; P < 0.01] and having a primary caregiver who tested the temperature of food with their tongue before feeding the child (OR = 2.4; 95% CI, 1.93-3.30; P =0.01). Breastfeeding was protective against infection with HHV-8 for children (OR= 0.3; 95% CI, 0.16-0.72; P < 0.01). CONCLUSIONS: These results indicate that exposure to HHV-8 in the household increases risk for early childhood infection, with specific feeding behaviors likely playing a role in transmission. IMPACT: Interventions to protect children from infection should emphasize the possibility of infection through sharing of foods. en_US
dc.language.iso en_US en_US
dc.publisher American Association for Cancer Research en_US
dc.subject Human herpesvirus 8 en_US
dc.subject Kaposi’s sarcoma en_US
dc.subject Herpesviridae Infections en_US
dc.subject Feeding behavior en_US
dc.subject Africa, Sub-Saharan en_US
dc.subject Zambia en_US
dc.title Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: The role of early childhood feeding practices en_US
dc.type Article en_US


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